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  • Title: Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis).
    Author: Adamson I, Okafor C, Abu-Bakare A.
    Journal: Enzyme; 1986; 36(3):212-5. PubMed ID: 3026798.
    Abstract:
    The levels of the three ATPases found in the erythrocyte membrane of diabetic patients were significantly lower than normal subjects. The distribution of the enzymes was also different. Na+,K+-ATPase and Mg2+-ATPase reflected the status of blood glucose more than Ca2+-ATPase. The ratio between two of the ATPases was sensitive to glycemic response. When dikanut, a viscous preparation, was fed to diabetics for 4 weeks, blood glucose became normal and the activities of the three ATPases increased significantly. The ratio among the enzymes also approached that of normal subjects. A relationship was found between the blood glucose level and erythrocyte membrane ATPases which, if linked to insulin binding or level, may provide a rapid inexpensive assay in diabetes research.
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