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  • Title: Effect of calcium on the structure-function relationship of (Na+ + K+)-ATPase in cardiac sarcolemma.
    Author: Vrbjar N, Breier A, Ziegelhöffer A, Dzurba A, Soós J.
    Journal: Gen Physiol Biophys; 1986 Oct; 5(5):545-9. PubMed ID: 3026889.
    Abstract:
    Calcium-induced changes in (Na+ + K+)-ATPase activity and structural changes of membrane bound proteins in rat heart sarcolemma were investigated. Increasing concentrations of Ca2+ (0.1-8.0 mmol.l-1) gradually inhibited the (Na+ + K+)-ATPase activity and decreased the alpha-helix content of sarcolemmal proteins. Mathematical and graphical analysis of observed data yielded a quantitative relationship between Ca2+-induced changes in (Na+ + K+)-ATPase activity and the secondary structure of membrane proteins in cardiac sarcolemma.
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