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  • Title: Polymyxin B and polymyxin B nonapeptide alter cytoplasmic membrane permeability in Escherichia coli.
    Author: Dixon RA, Chopra I.
    Journal: J Antimicrob Chemother; 1986 Nov; 18(5):557-63. PubMed ID: 3027012.
    Abstract:
    The effects of polymyxin B and polymyxin B nonapeptide (PMBN) on the permeability of the Escherichia coli cytoplasmic membrane were investigated. Both compounds caused loss of free amino acids, uracil and K+ from E. coli. The rates of loss promoted by polymyxin B were one and a half to two-fold greater than those caused by PMBN. Although PMBN mediated loss of low molecular weight substances from E. coli, it was not bactericidal. In contrast, polymyxin B treated E. coli lysed and rapidly lost viability. We suggest that the bactericidal activity of polymyxin B may be related to its previously reported ability to release cytoplasmic proteins from bacteria.
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