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  • Title: Met-enkephalin stimulates secretion of ACTH in sheep.
    Author: Wang XM, Coghlan JP, Congiu M, Scoggins BA, Wintour EM.
    Journal: J Endocrinol; 1986 Dec; 111(3):463-7. PubMed ID: 3027227.
    Abstract:
    The ability of opioid peptides to affect plasma immunoreactive ACTH concentrations was examined in conscious sheep. Plasma concentrations of ACTH were significantly increased by an i.v. infusion of Met-enkephalin and its analogue (FK-33824). There was a dose-dependent increase in plasma concentrations of ACTH with a graded administration of FK-33824. The combined effect of Met-enkephalin and ovine corticotrophin-releasing factor (oCRF) or FK-33824 and oCRF on plasma concentrations of ACTH was greater than the effect of each peptide when given individually. This study demonstrates that Met-enkephalin and its analogue stimulate ACTH release in sheep.
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