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  • Title: Diuretic actions in man of a selective kappa opioid agonist: U-62,066E.
    Author: Peters GR, Ward NJ, Antal EG, Lai PY, deMaar EW.
    Journal: J Pharmacol Exp Ther; 1987 Jan; 240(1):128-31. PubMed ID: 3027300.
    Abstract:
    The effect of a selective kappa opioid agonist, U-62,066E, on urine formation in human volunteers was assessed. Volunteers received single intramuscular injections of either placebo or 2, 3, 4, 5 or 6 micrograms/kg of U-62,066E in a randomized, double-blind study. U-62,066E caused dose-dependent maximal increases in urine volume of 2.6 times control in the first 4 hr after administration. A corresponding decrease in urine osmolality to 20% of base-line values occurred. No changes in total urinary Na, K or Cl excretion were identified. Kappa agonists produce a water-only diuresis at low doses in humans. The mechanism of this effect was not examined in this study but probably relates to alterations in antidiuretic hormone activity.
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