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  • Title: Role of the agnoprotein in regulation of simian virus 40 replication and maturation pathways.
    Author: Hou-Jong MH, Larsen SH, Roman A.
    Journal: J Virol; 1987 Mar; 61(3):937-9. PubMed ID: 3027418.
    Abstract:
    Analysis of two agnogene mutants, dl2304 deleted over the entire agnogene and in2379 carrying a 2-base insert, indicated that the mutant phenotype of small plaque formation must be the result of a defect late in the maturation pathway. Both mutants were removed from the pool of molecules available for replication with wild-type kinetics. Whereas dl2304 was somewhat reduced in its rate of progression from chromatin to previrions-virions, in2379, which produced even smaller plaques than dl2304 did, progressed with wild-type kinetics. Therefore, the agnoprotein was not required for progression from chromatin to previrions.
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