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  • Title: Acute effects of alpha-MSH on the rat zona glomerulosa in vivo.
    Author: Nussdorfer GG, Mazzocchi G, Malendowicz LK.
    Journal: Biochem Biophys Res Commun; 1986 Dec 30; 141(3):1279-84. PubMed ID: 3028391.
    Abstract:
    alpha-MSH acutely enhanced the plasma concentration of aldosterone (but not that of corticosterone) in the rat, with a maximal response at a dose of 100 micrograms/kg. This dose of alpha-MSH increased the blood level o aldosterone and the activity of 11 beta-hydroxylase and 18-hydroxylase of capsular adrenals in rats infused for 24 h with dexamethasone, dexamethasone plus ACTH, or captopril plus angiotensin II, but not in animals treated with captopril alone. The plasma concentration of corticosterone and the activity of 11 beta-hydroxylase in the inner adrenal layers were not changed. These findings indicate that alpha-MSH is specifically involved in the acute stimulation of the late steps of the secretory activity of the rat zona glomerulosa, and that this action of alpha-MSH requires a normal level of circulating angiotensin II.
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