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  • Title: Angiotensin-induced formation and metabolism of inositol polyphosphates in bovine adrenal glomerulosa cells.
    Author: Guillemette G, Baukal AJ, Balla T, Catt KJ.
    Journal: Biochem Biophys Res Commun; 1987 Jan 15; 142(1):15-22. PubMed ID: 3028399.
    Abstract:
    The actions of angiotensin II (AII) on inositol polyphosphate production and metabolism were analyzed in cultured bovine adrenal glomerulosa cells. In cells labeled for 24 hr with [3H]inositol, AII caused a rapid and prominent rise in formation of Ins-P3 (mainly the Ins-1,3,4,-P3 isomer) and of Ins-P4, with marked increases in two isomers of Ins-P2 and Ins-P. These findings are consistent with rapid formation and turnover of Ins-1,4,5-P3, partly via conversion to Ins-1,3,4,5-P4 with subsequent metabolism to Ins-1,3,4-P3 and lower inositol phosphates. The demonstration of a cytosolic Ins-P3-kinase gave further evidence for the presence of the tris/tetrakisphosphate pathway and Ins-P4 synthesis during AII action in the bovine adrenal cortex.
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