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  • Title: Leukotrienes and related eicosanoids are produced by frog leukocytes.
    Author: Green FA, Herman CA, Herman RP, Claesson HE, Hamberg M.
    Journal: Biochem Biophys Res Commun; 1987 Jan 30; 142(2):309-14. PubMed ID: 3028410.
    Abstract:
    The metabolites of inflammatory cells produced by massive infection of the peritoneal cavity of two related European species of frogs, Rana temporaria and Rana arvalis were examined for lipoxygenase-generated products of exogenous arachidonic acid. Cells of Rana temporaria produced large amounts of 5-hydroxyeicosatetraenoic acid and leukotriene B4. Cells from Rana arvalis produced only 15-hydroxyeicosatetraenoic acid. This is the first unequivocal demonstration of such enzyme activity in lower vertebrates. There was a trend towards increased mortality in the species without evidence of 5-lipoxygenase activity.
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