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  • Title: Phase II study of carboplatin in previously untreated patients with metastatic small cell lung carcinoma.
    Author: Jacobs RH, Bitran JD, Deutsch M, Hoffman PC, Sinkule J, Purl S, Golomb HM.
    Journal: Cancer Treat Rep; 1987 Mar; 71(3):311-2. PubMed ID: 3028621.
    Abstract:
    Fourteen previously untreated patients with metastatic small cell lung carcinoma (SCLC) were treated with carboplatin, 400 mg/m2, given as a 1-hour infusion every 28 days. Eleven patients had a partial response to therapy [response rate, 79% (95% confidence limits, 57%-100%)]. The median duration of response was 8 weeks (range, 4-41) and the median survival was 29 weeks (range, 11-68+). Hematologic toxicity was limited to one patient who developed World Health Organization (WHO) grade IV thrombocytopenia; no patient developed infection due to granulocytopenia. Nonhematologic toxicity was limited to WHO grade I and II nausea and vomiting. This study demonstrates that carboplatin is a highly active drug in SCLC with minimal toxicity. Future studies should evaluate its use in combination with other chemotherapeutic drugs in SCLC.
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