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  • Title: Papaverine-induced positive inotropism with failure to increase cyclic AMP in rat atria.
    Author: Aramendía P, Eisenschlos CD, Márquez MT.
    Journal: Eur J Pharmacol; 1986 Nov 12; 131(1):141-4. PubMed ID: 3028824.
    Abstract:
    Phosphodiesterase inhibition by papaverine is likely to play a minor role in the rat atrial inotropic response because non-significant changes in cyclic AMP were obtained. Isoprenaline however raised the nucleotide levels three-fold and up to seventeen-fold when papaverine was added in a similar preparation. A prominent effect of papaverine was to lengthen relaxation instead of shortening it as did isoprenaline. The results suggest different sites of action, although overlapping effects cannot be excluded.
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