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  • Title: Modulation of somatostatin binding sites in cytosol of rabbit gastric fundic mucosa by cysteamine administration.
    Author: Gonzalez-Guijarro L, López-Ruiz MP, Prieto JC, Arilla E.
    Journal: Gen Pharmacol; 1986; 17(6):637-9. PubMed ID: 3028901.
    Abstract:
    Cysteamine, when given in vivo to rabbits, depleted immunoreactive somatostatin in rabbit gastric fundic mucosa. Depletion of immunoreactive somatostatin was associated with both an increase in the number and a decrease in the affinity of the low-affinity somatostatin binding sites. The in vitro incubation of cysteamine (0.1 mM) with the cytosolic fraction did not result in any modification of somatostatin binding. These results suggest that a decrease in the endogenous immunoreactive somatostatin might lead to up-regulation of somatostatin binding sites in the gastric fundic mucosa.
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