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  • Title: Cyclic 3':5'-adenosine monophosphate phosphodiesterase and cyclic 3':5'-guanosine monophosphate phosphodiesterase of normal granulocytes and granulocytes of chronic myelogenous leukaemia.
    Author: Uciński WS, Naskalski JW.
    Journal: Haematologia (Budap); 1986; 19(4):275-83. PubMed ID: 3028916.
    Abstract:
    Normal human neutrophilic granulocytes and granulocytes of chronic myelogenous leukaemia (CML) were shown to possess only the "high Km type" isoenzyme of cAMP-phosphodiesterase. The properties of this enzyme are similar in both normal and CML granulocytes. cGMP-phosphodiesterase in human granulocytes was found to be composed of "high Km type" and "low Km type" isoenzymes. The high Km cGMP-phosphodiesterase of CML granulocytes showed a considerably lower apparent Km and Vm value than those in normal neutrophilic granulocytes.
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