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  • Title: YKT6 as a second SNARE protein of mammalian autophagosomes.
    Author: Mizushima N, Matsui T, Yamamoto H.
    Journal: Autophagy; 2019 Jan; 15(1):176-177. PubMed ID: 30290708.
    Abstract:
    Mammalian autophagosomes possess the Qa-SNARE STX17 (syntaxin 17) for fusion with lysosomes. However, STX17 is not absolutely required for fusion because STX17 knockout cells partially retain autophagosome-lysosome fusion activity. We recently identified YKT6, an R-SNARE, as another autophagosomal SNARE protein that acts independently of STX17 in mammals. Here, we discuss the features and functions of autophagosomal SNARE proteins by comparing STX17 and YKT6. Abbreviations: SNARE, soluble N-ethylmaleimide-sensitive factor attachment protein receptor; STX17, syntaxin 17.
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