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  • Title: Further evidence for tonically functioning presynaptic beta-adrenoceptors in guinea-pig pulmonary arteries.
    Author: Kuwahara M, Amano H, Kubo T, Misu Y.
    Journal: Arch Int Pharmacodyn Ther; 1986 Dec; 284(2):225-30. PubMed ID: 3030211.
    Abstract:
    Effects of dl- and d-carteolol alone on the release of tritium evoked by transmural field stimulation at 1 Hz were investigated in spirally cut guinea-pig pulmonary arteries preloaded with [3H]-norepinephrine. Cumulatively applied dl-carteolol 10(-8) M, 10(-7) M and 10(-6) M readily inhibited the release of tritium in a concentration-dependent manner, whereas the same concentrations of d-carteolol produced no effect. In conclusion, presynaptic beta-adrenoceptors in guinea-pig pulmonary arteries tonically function to facilitate the release of the transmitter norepinephrine.
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