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  • Title: Substances affecting the infection and replication of human immunodeficiency virus (HIV).
    Author: Yamamoto N, Harada S, Nakashima H.
    Journal: AIDS Res; 1986 Dec; 2 Suppl 1():S183-9. PubMed ID: 3030346.
    Abstract:
    The effects of various compounds were studied quantitatively on the growth of human immunodeficiency virus (HIV). For this we used a human T-cell leukemia virus type I carrying cell line, MT-4 which is most permissive for HIV infection. The results are summarized as follows: 1) Prostaglandin E2 and 12-0-tetradecanoylphorbol-13-acetate enhanced the production of HIV significantly in MT-4 cells as well as a continuous HIV producer Molt-4/HTLV-III cells. 2) Interferon gamma, retinoic acid and 3'-azido-3'-deoxythymidine inhibited the replication of HIV at the concentrations which were not cytotoxic. Mechanism of action of these compounds and its clinical implications are discussed.
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