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  • Title: Idiotypic specificity of a human monoclonal anti-Rhesus(D) antibody.
    Author: Lambin P, Rouger P, Goossens D, Hérance N, de Saint Martin J, Fine JM, Salmon C.
    Journal: Ann Inst Pasteur Immunol; 1986; 137D(3):383-90. PubMed ID: 3030361.
    Abstract:
    A human monoclonal IgG anti-Rhesus(D) (H2D5D2) obtained after transformation of lymphoid cells by Epstein-Barr virus was purified from culture supernatant by affinity chromatography. Rabbits were immunized with the monoclonal anti-D. The rabbit antisera, after appropriate absorption, reacted only against the immunizing monoclonal anti-D. The antiidiotypic antibodies (anti-id ab) were purified and gave a complete inhibition of the monoclonal anti-D, whereas no inhibition was observed with monoclonal or polyclonal IgG or with sera containing high titres of anti-D. Polyclonal anti-D obtained from 118 immunized blood donors were coated on Rh-positive red cells. Agglutination by anti-id ab was observed in 4 cases (3.4%), indicating a cross-reactivity between the monoclonal anti-D and the polyclonal anti-D present in the sera of some immunized donors.
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