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  • Title: Calpain abolishes the effect of filamin on the actomyosin system in platelets.
    Author: Onji T, Takagi M, Shibata N.
    Journal: Biochim Biophys Acta; 1987 Apr 08; 912(2):283-6. PubMed ID: 3030436.
    Abstract:
    Platelet filamin was shown to cross-link F-actin and inhibit actomyosin ATPase activity. Filamin was also shown to be degraded by calpain (calcium-activated neutral proteinase; CANP) when the platelet was activated. The consequences of the proteolysis of filamin on the actomyosin system have been investigated. When degraded by calpain in the presence of Ca2+, filamin loses its ability to cross-link F-actin. Under the same conditions, its inhibitory effects on the superprecipitation and ATPase activity of actomyosin are abolished. The result suggests that the degradation of filamin is favorable for contraction of the activated platelets.
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