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  • Title: [Interaction of alpha-tocopherol with free fatty acids. Mechanism of stabilization of lipid bilayer microviscosity].
    Author: Erin AN, Gorbunov NV, Skrypin VI, Kagan VE, Prilipko LL.
    Journal: Nauchnye Doki Vyss Shkoly Biol Nauki; 1987; (1):10-6. PubMed ID: 3030452.
    Abstract:
    Using ESR-spin probes and 1H-NMR-spectroscopy methods the effect of alpha-tocopherol on liposome microviscosity has been studied. alpha-Tocopherol has been shown to remove the chaotropic action of free fatty acids on bilayer. The stabilization effect found has a common nature and does not depend on the chemical structure of the phopsholipid functional polar groups, the unsaturation degree of free fatty acids as well as fatty acids residua entering into phospholipid composition. Analog of alpha-tocopherol without phytol chain 2,2,5,7,8-penthamethyl-6-oxychroman does not show the stabilizing effect on the microviscosity of lipid bilayer under the action of free fatty acids. It indicates that both chromanol nucleus and phytol chain of alpha-tocopherol molecule are necessary for stabilizing action. The data obtained allow to suppose that the interaction of alpha-tocopherol with free fatty acids may be one of the molecular mechanisms of lipid bilayer microvicosity stabilization.
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