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  • Title: Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by ascorbic acid. Implications for antioxidant protection in the inflamed rheumatoid joint.
    Author: Halliwell B, Wasil M, Grootveld M.
    Journal: FEBS Lett; 1987 Mar 09; 213(1):15-7. PubMed ID: 3030805.
    Abstract:
    Ascorbic acid, at physiological concentrations, can scavenge the myeloperoxidase-derived oxidant hypochlorous acid at rates sufficient to protect alpha 1-antiprotease against inactivation by this molecule. The rapid depletion of ascorbic acid at sites of inflammation, as in the inflamed rheumatoid joint, may therefore facilitate proteolytic damage.
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