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  • Title: Association between AGTR1 A1166C polymorphism and the susceptibility to diabetic nephropathy: Evidence from a meta-analysis.
    Author: Zhuang Y, Niu F, Liu D, Sun J, Zhang X, Zhang J, Guo S.
    Journal: Medicine (Baltimore); 2018 Oct; 97(41):e07689. PubMed ID: 30313019.
    Abstract:
    BACKGROUND: Diabetic nephropathy (DN) is a common complication in patients with diabetic mellitus (DM). Growing evidences have demonstrated that the polymorphisms of angiotensin II receptor type 1 (AGTR1) showed significant association with DN onset, but no consensus has been achieved yet. Therefore, we performed this meta-analysis to combine the findings of previous researches for a more comprehensive conclusion. METHODS: Eligible publications were identified through electronic databases. The intensity of the correlation between AGTR1 A1166C polymorphism and DN susceptibility was evaluated through calculating pooled odds ratios (ORs) with their 95% confidence intervals (95% CIs). Heterogeneity among included studies was examined with Q test. When P-value less than .05, significant heterogeneity presented, random-effects model was used to calculate the pooled ORs, otherwise, the fixed-effects model was used. Stratification analyses were also performed based on ethnicity and the type of DM. RESULTS: Seventeen eligible articles were finally included in the present meta-analysis. The analysis results showed that AGTR1 A1166C polymorphism was significantly related to increased risk of DN under CC versus AA (OR = 1.723, 95% CI = 1.123-2.644), CC + AC versus AA (OR = 1.179, 95% CI = 1.004-1.383), CC versus AA + AC (OR = 1.662, 95% CI = 1.112-2.486), and C versus A (OR = 1.208, 95% CI = 1.044-1.397) genetic models. Additionally, a similar result was also found in Asian and T2DM (type 2 diabetic mellitus) groups after subgroup analyses of ethnicity and DM type. CONCLUSION: AGTR1 A1166C polymorphism may increase the susceptibility to DN, especially in Asians and T2DM population.
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