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  • Title: Properties of a U1 RNA enhancer-like sequence.
    Author: Ciliberto G, Palla F, Tebb G, Mattaj IW, Philipson L.
    Journal: Nucleic Acids Res; 1987 Mar 25; 15(6):2403-16. PubMed ID: 3031597.
    Abstract:
    The properties of a X.laevis U1B snRNA gene enhancer have been studied by microinjection in Xenopus oocytes. The enhancer-like sequence, defined as a short DNA stretch that is able to activate transcription in an orientation independent manner, is interchangeable between different U snRNA genes. The enhancer sequence alone does not, however, efficiently activate transcription from an SV40 pol II promoter but regains its activity when combined with the U-gene specific proximal sequence element. DNase I protection experiments show that the X.laevis U1B enhancer can interact specifically with a nuclear factor present in mammalian cells.
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