These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A highly sensitive and selective fluorescent probe for determination of Cu (II) and application in live cell imaging.
    Author: Fu Y, Pang XX, Wang ZQ, Chai Q, Ye F.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2019 Feb 05; 208():198-205. PubMed ID: 30316129.
    Abstract:
    A highly sensitive fluorescent probe, 2‑butyl‑6‑(2‑ethylidenehydrazinyl)‑1H‑benzo[de]isoquinoline‑1,3(2H)‑dione (P) has been designed and synthesized to detect Cu2+ in CH3CN-HEPES (4:1, v/v, pH = 7.4) solution. This probe functions via a distinctive hydrolysis mechanism through Cu2+-promoted accompany by extinction of the fluorescent and other competing metal ions did not showed any interference. The limit of detection toward Cu2+ was calculated of 320 nM. Probe P was not only successfully used for the determination of trace level Cu2+ in the CH3CN-HEPES (4:1, v/v, pH = 7.4) solution, but also valid for fluorescence imaging of Cu2+ in lysosomes of 293T cells and it was applied in real water samples. This work indicated that P would be of great application prospect in environmental monitoring and medical diagnosis.
    [Abstract] [Full Text] [Related] [New Search]