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  • Title: ATP stimulates inositol phosphates accumulation and calcium mobilization in a primary culture of rat aortic myocytes.
    Author: Phaneuf S, Berta P, Casanova J, Cavadore JC.
    Journal: Biochem Biophys Res Commun; 1987 Mar 13; 143(2):454-60. PubMed ID: 3032169.
    Abstract:
    The effects of extracellular ATP on phosphoinositide metabolism and intracellular Ca2+ concentration were studied in a primary culture of rat aortic myocytes. ATP increases the level of inositol phosphates, the putative second messenger for Ca2+ mobilization. No saturation of inositol phosphates accumulation is obtained (up to 10(-2) M ATP). Under the same conditions, ATP rapidly mobilizes intracellular Ca2+ in fura-2 loaded myocytes. The mobilization of intracellular Ca2+ is dose-dependent (maximal at 10(-4) M ATP), and is not affected by addition of EGTA. It is concluded that the receptors mediating the cytosolic increase of Ca2+ are of the P2-purinoceptor subtype. The physiological functions of these receptors are not presently known.
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