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  • Title: Inhibition by p-nitrophenylphosphate of acetylcholine release induced by Na+-deprivation.
    Author: Vizi ES, Ronai A, Bernath S.
    Journal: Biochem Pharmacol; 1987 Mar 15; 36(6):803-7. PubMed ID: 3032196.
    Abstract:
    The effect of p-nitrophenylphosphate (p-NPP) on the release of acetylcholine evoked by drugs and ionic environments known to inhibit Na+, K+-ATPase was studied in isolated cortical slices of rat brain and longitudinal muscle strip of guinea-pig ileum. p-NPP inhibited the release of acetylcholine induced by sodium deprivation provided that the circumstances were in favour of the function of the K+-activated part of ATPase. However, it failed to antagonize the increase in the acetylcholine release elicited by omission of K+ or by administration of ouabain. Therefore it is concluded that the K+-stimulated phosphatase moiety of the Na+, K+-ATPase might be involved in the release of acetylcholine.
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