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  • Title: Alterations of carboxypeptidases N activities in patients with thyroid dysfunction.
    Author: Schweisfurth H, Pickert E, Gramer E, Reiners C.
    Journal: Clin Biochem; 1987 Feb; 20(1):43-6. PubMed ID: 3032478.
    Abstract:
    Serum carboxypeptidases N (EC. 3.4.17.3) were determined spectrophotometrically in 87 patients with disturbances of thyroid function and in 131 euthyroid individuals, including 33 women taking estrogens for contraception. Carboxypeptidases N (CN) can be subdivided into CN1 and CN2, according to variable substrate affinity. In addition, measurements of blood pressure and in vitro tests of thyroid function were performed. In euthyroid controls, CN1 was negatively correlated with age. No significant differences between CN1 and CN2 have been observed with regard to sex. In patients with hyperthyroidism, the mean values of both enzymes were elevated, but this tendency proved to be significant only for CN2. In hypothyroid patients CN1 and CN2 levels were normal. Elevations of CN1 and CN2 in the hyperthyroid state seem not to be related to underlying immunological processes but to the thyroid hormone excess itself. In euthyroid women taking estrogens for contraception CN2 was also elevated. The serum enzymes called carboxypeptidase N that split arginine or lysine from certain peptides, here termed CN1 and CN2, were determined in patients with thyroid disorders and in women taking oral contraceptives. The assays were done spectrophotometrically using synthetic hippuryl-substrates. The normal ranges in euthyroid subjects were 13-49 Units/1 for CN1 and 71-181 for CN2. In normal subjects, CN1 was inversely correlated with age. In hyperthyroid patients, the levels of both enzymes were elevated, significant only for CN2. Mean CN2 was significantly elevated in 33 women taking oral contraceptives, compared to euthyroid controls, 148.6 u/1, but was not outside the normal range.
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