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  • Title: The prophylactic use of polyvinylpyridine-N-oxide (PVNO) in baboons exposed to quartz dust.
    Author: Goldstein B, Rendall RE.
    Journal: Environ Res; 1987 Apr; 42(2):469-81. PubMed ID: 3032603.
    Abstract:
    Twelve baboons were exposed to a quartz dust cloud. Four of these were also given polyvinylpyridine-N-oxide (PVNO) by aerosol and four received PVNO by aerosol and injection. A prophylactic effect was demonstrated during the course of treatment, but when treatment stopped the silicosis progressed to the same degree of severity as in the untreated animals.
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