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  • Title: Comparative in vitro activity of LY146032 (daptomycin), a new lipopeptide antimicrobial.
    Author: Hodinka RL, Jack-Wait K, Wannamaker N, Walden TP, Gilligan PH.
    Journal: Eur J Clin Microbiol; 1987 Feb; 6(1):100-3. PubMed ID: 3032607.
    Abstract:
    The in vitro activity of LY146032, a new cyclic lipopeptide antibiotic, was compared with those of vancomycin, teicoplanin, and either oxacillin or ampicillin by determining agar dilution MIC values for 304 clinical gram-positive isolates. LY146032 had superior in vitro activity against oxacillin-resistant staphylococci when compared to vancomycin or teicoplanin. Against oxacillin-sensitive staphylococci, group JK-diphtheroids, streptococci, Listeria monocytogenes and Clostridium difficile, LY146032 was equally or less active than vancomycin, teicoplanin, or the penicillins tested. When tested by macrobroth dilution MIC/MBC, LY146032 showed good bactericidal activity against all organisms with the exception of Clostridium difficile.
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