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  • Title: Comparative in vitro activity of LY146032 (daptomycin) against gram-positive cocci.
    Author: Machka K, Braveny I.
    Journal: Eur J Clin Microbiol; 1987 Feb; 6(1):96-9. PubMed ID: 3032613.
    Abstract:
    The in vitro activity of LY146032 was compared with those of seven other antimicrobial agents against gram-positive cocci. MICs of LY146032 were lowest for Streptococcus pneumoniae and methicillin-susceptible Staphylococcus epidermidis (0.25 mg/l). For methicillin-resistant Staphylococcus epidermidis and Staphylococcus aureus the MICs were 1 mg/l, for Enterococcus faecalis 2 mg/l and for Enterococcus faecium 4 mg/l. The activity of LY146032 was in general higher than that of vancomycin. Time-kill studies showed LY146032 had higher bactericidal activity than vancomycin against a methicillin-resistant Staphylococcus aureus strain, and bactericidal activity against Enterococcus faecalis and Enterococcus faecium.
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