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  • Title: Sidedness of ceramide-phosphoethanolamine synthesis on rat liver and brain microsomal membranes.
    Author: Malgat M, Maurice A, Baraud J.
    Journal: J Lipid Res; 1987 Feb; 28(2):138-43. PubMed ID: 3033117.
    Abstract:
    Phosphatidylethanolamine:ceramide-ethanolamine-phosphotransferase catalyzes the synthesis of ceramide-phosphoethanolamine, a sphingomyelin analogue. Its localization was studied in rat liver and brain microsomes. After testing the integrity and the sidedness of microsomal vesicles, trypsin treatment of intact or deoxycholate-disrupted microsomes made it possible to conclude that both the transferase and the ceramide-phosphoethanolamine are located in the cisternal leaflet of the membrane bilayer. Using trinitrobenzenesulfonic acid as a probe, no trace of newly synthesized ceramide-phosphoethanolamine was detectable on the cytoplasmic side of the microsomes.
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