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  • Title: δ-Tocopherol promotes thermogenic gene expression via PGC-1α upregulation in 3T3-L1 cells.
    Author: Tanaka-Yachi R, Shirasaki M, Otsu R, Takahashi-Muto C, Inoue H, Aoki Y, Koike T, Kiyose C.
    Journal: Biochem Biophys Res Commun; 2018 Nov 17; 506(1):53-59. PubMed ID: 30336984.
    Abstract:
    Activation of thermogenic adipocytes (brown and beige) has been considered an attractive target for weight loss and treatment of metabolic disease. Peroxisome proliferator-activated receptor γ co-activator-1 α (PGC1-α) is a master regulator of thermogenic gene expression in thermogenic adipocytes. We previously reported that α-tocopherol upregulated PGC-1α gene expression and promoted thermogenic adipocyte differentiation in mammalian adipocytes. In this study, we investigated the effects of the vitamin E analogs (α-, γ- and δ-tocopherol) on PGC-1α and uncoupling protein 1 (UCP1) gene expression in 3T3-L1 cells. The expression of PGC-1α and UCP1 increased significantly with the addition of δ-tocopherol. In δ-tocopherol-treated cells, nuclear translocation of PGC-1α increased, as did p38 mitogen-activated protein kinase (MAPK) expression and phosphorylation. Our results suggest that p38 MAPK activation by δ-tocopherol contributes to PGC-1α activation and UCP1 induction.
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