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  • Title: Effect of a high carbohydrate diet on cardiac alpha-1 and beta adrenoceptors.
    Author: Limas CJ, Limas C.
    Journal: Biochem Biophys Res Commun; 1987 Apr 14; 144(1):238-43. PubMed ID: 3034244.
    Abstract:
    Short-term (2 weeks) administration of a high-fructose diet to euthyroid Sprague-Dawley rats results in a significant (18%) increase of cardiac beta-adrenoceptors without any change in their affinities or their distribution between the plasma membrane and a vesicular fraction. A much smaller increase occurs in the number of alpha 1-adrenoceptors (8% higher than in rats fed a regular diet). The high-carbohydrate diet induced a 39% increase in beta-adrenoceptor numbers/heart in hypothyroid animals and a 19% increase in the total number of alpha 1-adrenoceptors. These results strongly suggest that changes in cardiac performance after dietary manipulations may be mediated, in part, through enhancement of adrenergic pathways.
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