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  • Title: Genetic and cellular control of spontaneous autoimmune thyroiditis in OS chickens.
    Author: Bacon LD, Sundick RS, Rose NR.
    Journal: Adv Exp Med Biol; 1977; 88():309-18. PubMed ID: 303450.
    Abstract:
    B-locus genotypes have been defined in Obese strain (OS) chickens that spontaneously develop autoimmune thyroiditis (SAT), and in White Leghorn Cornell C strain (CS) chickens from which the OS was selected. The B-locus influences SAT, and some possible mechanisms are discussed. Thymic abnormalities in OS, as contrasted with CB birds, are also discussed and may play a role in SAT, as may an intrinsic defect in the thyroid gland itself.
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