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  • Title: [CMC chemotherapy regimen combined with surgery of small cell lung cancer (SCLC)].
    Author: Liao ML, Xu CW, Huang OL, Zhou YZ, Cao YF, Chen YR.
    Journal: Zhonghua Zhong Liu Za Zhi; 1986 Nov; 8(6):453-5. PubMed ID: 3034537.
    Abstract:
    From Dec. 1982 to Oct. 1984, 35 patients with SCLC proved by pathology or cytology, were treated by cyclophosphamide + methotrexate + CCNU (CMC) regimen combined with surgery in our hospital. All the patients received chemotherapy for more than 2 courses and the overall response rate was 85.7%, complete remission (CR) rate was 14.3%. Toxic reactions were tolerable to the patients. Treatment result was better in SCLC with localized than extensive disease. Operation was done for 9 out of 21 patients with localized lesions which had responded to chemotherapy. Of them, 1 died of postoperative complication, 2 were lost in follow-up and the rest 6 were disease-free for 8-32 months with a median survival time of 19 months. The 1 year survival rate was 75%. The results indicate that in limited disease of SCLC, successful chemotherapy combined with surgery can prolong the survival time. For patients with an limited disease which has given a CR, surgical resection should be strived for.
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