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  • Title: [Intensity of the synthesis of RNA precursors in blood lymphocytes of cattle infected with leukemia virus].
    Author: Kuznetsova NV, Simovart IuA, Nikol'skaia TA.
    Journal: Eksp Onkol; 1987; 9(2):30-3. PubMed ID: 3034548.
    Abstract:
    The peripheral blood lymphocytes of the cattle with lymphatic leukemia experimentally induced by BLV and of the animals from the same group with persistent lymphocytosis show the lower level of the pre-RNA-synthetic activity per cell when compared with the lymphocytes of healthy cattle (as evaluated by autoradiography with 3H-uridine as a precursor). At the same time the RNA-synthetic activity in the population as a whole increases as a result of growth of the RNA synthesizing cells (a labelling index), which is confirmed by enhancement of DNA-dependent RNA-polymerase activities and 3H-uridine in vitro incorporation into lymphocytes revealed by the liquid scintillation counting method.
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