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  • Title: [Complex evaluation of the proliferative activity of tumor cells in different histological variants of lung cancer].
    Author: Kazantseva IA, Makhmudova GK, Kotel'nikov VM.
    Journal: Eksp Onkol; 1987; 9(2):42-6. PubMed ID: 3034549.
    Abstract:
    Mitotic regime, labelling index and DNA distribution in malignant lung tumours of different histological types (47 cases) were investigated. The most pronounced proliferative activity in combination with high incidence of three group metaphases and multipolar mitoses of bi- and polyclonal cases of undifferentiated cancer and poorly differentiated squamous cell carcinoma were established. Well-differentiated tumours were monoclonal and usually had a low labelling index. The high incidence of c-mitoses in well-differentiated squamous cell carcinomas is, probably, an evidence for a more pronounced damage of their cell multiplication.
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