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  • Title: A study of cyclic nucleotides as second messengers after interleukin 2 stimulation of human T lymphocytes.
    Author: Knudsen TE, Larsen CS, Johnsen HE.
    Journal: Scand J Immunol; 1987 May; 25(5):527-31. PubMed ID: 3035707.
    Abstract:
    Interleukin 2 (IL-2) was shown to induce a small but significant increase in the level of cGMP after 20 min stimulation and a subsequent fall after 1 h in activated T lymphocytes. No change in the level of cAMP was observed. Addition of the cyclic nucleotide analogues dbcAMP or dbcGMP did not stimulate DNA synthesis. On the contrary, IL-2-induced [3H]thymidine incorporation was inhibited by these drugs. Further, the phosphodiesterase inhibitor theophylline inhibited proliferation of activated T lymphocytes. Our results indicate that neither cAMP nor cGMP act as 'second messengers' for IL-2 but support the theory that cAMP is a negative regulator of cell proliferation.
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