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  • Title: Alkylarylation of styrenes via direct C(sp3)-Br/C(sp2)-H functionalization mediated by photoredox and copper cooperative catalysis.
    Author: Yong X, Han YF, Li Y, Song RJ, Li JH.
    Journal: Chem Commun (Camb); 2018 Nov 13; 54(91):12816-12819. PubMed ID: 30357170.
    Abstract:
    For straightforward access to various substituted 1,1-diarylalkanes a photoredox-catalyzed and copper-promoted 1,2-alkylarylation reaction of styrenes has been developed, which uses α-carbonyl alkyl bromides and N,N-disubstituted anilines as functionalization reagents. In this radical difunctionalization reaction, α-carbonyl alkyl bromides, including primary-, secondary- and tertiary-α-bromoalkyl ketone esters, malonic esters and cycloalkane were transformed to the corresponding 1,1-diarylalkanes in moderate to good yields at room temperature. Notably, this transformation provided a new route for the C-H alkylation of N,N-disubstituted anilines with high para-selectivity beyond the typical Friedel-Crafts alkylation.
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