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  • Title: Callyspongidic Acids: Amphiphilic Diacids from the Tropical Eastern Pacific Sponge Callyspongia cf. californica.
    Author: Calabro K, Chalén BE, Genta-Jouve G, Jaramillo KB, Domínguez C, de la Cruz M, Cautain B, Reyes F, Thomas OP, Rodríguez J.
    Journal: J Nat Prod; 2018 Oct 26; 81(10):2301-2305. PubMed ID: 30360624.
    Abstract:
    The first chemical study of the marine sponge Callyspongia cf. californica widely distributed along the coasts of the Tropical Eastern Pacific led to the identification of a new family of amphiphilic derivatives called callyspongidic acids. The four isolated metabolites 1-4 feature a hydrophilic diacid end opposed to both an aromatic moiety and a long alkyl chain. They were evaluated against a panel of pathogenic microbes and seven tumoral cell lines, displaying moderate inhibitory properties against the A2058 melanoma cell line with an IC50 of 3.2 μM for callyspongidic acid C13:0 (2).
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