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  • Title: Septin 7 mediates high glucose-induced podocyte apoptosis.
    Author: Li R, Dong W, Zhang S, Yang H, Zhang L, Ye Z, Zhao X, Zhang H, Li Z, Xu L, Liu S, Shi W, Liang X.
    Journal: Biochem Biophys Res Commun; 2018 Nov 30; 506(3):522-528. PubMed ID: 30361092.
    Abstract:
    Podocyte depletion is a central pathological mechanism of diabetic nephropathy (DN). Hyperglycemia induced podocyte apoptosis, resulting in podocyte depletion. However, the crucial mechanism of hyperglycemia-induced podocyte apoptosis remains poorly understood. In this study, we evaluated the expression of septin 7, a GTP-binding protein, in glomerular podocytes of patients and mice with DN, and investigated the pro-apoptotic effect of septin 7 on high glucose (HG) induced podocyte apoptosis in vitro. We found septin 7 expression was markedly increased not only in glomerular podocytes of patients and db/db mice with DN but also in cultured podocytes with HG stimulation. Knocking down septin 7 with siRNA could attenuate HG induced podocytes apoptosis and excessive intracellular Ca2+ concentration. This study revealed septin7 may potentially play a proapoptotic role in podocyte under diabetic conditions and may provide a potential target for preventing podocyte apoptosis in DN.
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