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  • Title: Merkel cells in extraocular sebaceous carcinoma.
    Author: Fernandez-Flores A, Cassarino DS.
    Journal: J Cutan Pathol; 2019 Mar; 46(3):171-174. PubMed ID: 30362151.
    Abstract:
    INTRODUCTION: Mature sebaceous glands do not contain Merkel cells. Neither do sebaceous tumors in the vast majority of cases. Recently, however, it was showed that rare sebaceous adenomas with a carcinoid-like or labyrinthine pattern can contain intratumoral Merkel cells. Our purpose in this study is to examine for the presence of Merkel cells in extraocular sebaceous carcinomas. METHODS: Nineteen cases of extraocular sebaceous carcinoma were retrospectively studied with cytokeratin 20. RESULTS: One out of 19 cases (5.3%) contained Merkel cells in the basal layers of the tumoral nests of a sebaceous carcinoma from the cheek of a 76-year-old woman. CONCLUSIONS: Merkel cells are rarely evident in extraocular sebaceous carcinoma, and therefore, their evidence does not exclude this diagnosis.
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