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  • Title: Piptolinic acids F-J, five new lanostane-type triterpenoids from Piptoporus betulinus.
    Author: Khalilov Q, Li L, Liu Y, Tohtahon Z, Chen X, Aisa HA, Yuan T.
    Journal: Nat Prod Res; 2019 Nov; 33(21):3044-3051. PubMed ID: 30362364.
    Abstract:
    Five new lanostane-type triterpenoids, named piptolinic acids F - J (1-5), as well as seven known analogues (6-12), were isolated from methanolic extract of the fruiting bodies of Piptoporus betulinus. Compounds 1-4 were 24-methyl-lanostane triterpenoids, while compound 5 was a 3,4-seco-lanostane derivative. Their structures were established on the basis of extensive spectroscopic analysis (1D, 2D NMR, and HRESIMS). Cytotoxicity evaluation indicated that compound 6 exhibited moderate cytotoxic activity against human melanoma cell line A-375 (IC50 = 42.8 μM) and human renal carcinoma cell line 786-O (IC50 = 56.5 μM).
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