These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Inverse-Electron-Demand Diels-Alder Reactions for the Synthesis of Pyridazines on DNA.
    Author: Li H, Sun Z, Wu W, Wang X, Zhang M, Lu X, Zhong W, Dai D.
    Journal: Org Lett; 2018 Nov 16; 20(22):7186-7191. PubMed ID: 30365326.
    Abstract:
    The synthesis of pyridazines on DNA has been developed on the basis of inverse-electron-demand Diels-Alder (IEDDA) reactions of 1,2,4,5-tetrazines. The broad substrate scope is explored. Functionalized pyridazine products are selected for subsequent DNA-compatible Suzuki-Miyaura coupling, acylation, and SNAr substitution reactions, demonstrating the feasibility and versatility of IEDDA reactions for DNA-encoded library synthesis.
    [Abstract] [Full Text] [Related] [New Search]