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  • Title: IP3 receptors and store-operated Ca2+ entry: a license to fill.
    Author: Taylor CW, Machaca K.
    Journal: Curr Opin Cell Biol; 2019 Apr; 57():1-7. PubMed ID: 30368032.
    Abstract:
    Inositol 1,4,5-trisphosphate receptors (IP3Rs) are widely expressed intracellular Ca2+ channels that evoke large local increases in cytosolic Ca2+ concentration. By depleting the ER of Ca2+, IP3Rs also activate store-operated Ca2+ entry (SOCE). Immobile IP3Rs close to the plasma membrane (PM) are the only IP3Rs that respond to physiological stimuli. The association of these 'licensed' IP3Rs with the ER-PM junctions where STIM interacts with Orai PM Ca2+ channels may define the autonomous functional unit for SOCE. Ca2+ entering cells through SOCE can be delivered directly to specific effectors, or it may reach them only after the Ca2+ has been sequestered by the ER and then released through IP3Rs. This 'tunnelling' of Ca2+ through the ER to IP3Rs selectively delivers Ca2+ to different effectors.
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