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Title: [Expression and significance of endothelial microparticles in children with Henoch-Schönlein purpura].
Author: Fu SQ, Guo YJ, Song CL.
Journal: Zhongguo Dang Dai Er Ke Za Zhi; 2018 Oct; 20(10):831-834. PubMed ID: 30369358.
Abstract:
OBJECTIVE: To study the expression and significance of endothelial microparticles (EMPs) in children with Henoch-Schönlein purpura (HSP). METHODS: A total of 100 previously untreated children with HSP were classified to Henoch-Schönlein purpura nephritis (HSPN) group (n=40) and non-nephritis group (n=60). Thirty healthy children who underwent physical examination were enrolled as control group. Serum levels of EMPs, T helper 17 cells (Th17), and interleukin-17 (IL-17) were compared between groups. RESULTS: The HSPN and non-nephritis groups had significantly higher levels of Th17 and IL-17 than the control group, and the HSPN group had the highest levels (P<0.05). The HSPN and non-nephritis groups had a significantly higher level of EMPs than the control group, and the HSPN group had the highest level (P<0.05). In the HSPN group, the levels of Th17 and IL-17 were positively correlated with the level of EMPs (r=0.830 and 0.644 respectively; P<0.05). CONCLUSIONS: EMPs play an important role in the pathogenesis of HSP. The increase in EMPs might be one of the reasons for renal involvement in children with HSP. 目的: 探讨内皮细胞微粒(EMPs)在过敏性紫癜患儿中的表达及意义。方法: 100例初治过敏性紫癜患儿分为紫癜性肾炎组(HSPN组，40例)和非肾炎组(60例)，并以30例健康体检儿童为对照组。采用流式细胞术或ELISA方法检测各组血清EMPs、Th17及IL-17的表达或含量。结果: Th17及IL-17在HSP的肾炎组和非肾炎组均高于对照组，以HSPN组最高，差异有统计学意义(P < 0.05)。HSP肾炎组和非肾炎组的EMPs水平较对照组升高，以HSPN组最高，差异有统计学意义(P < 0.05)。紫癜性肾炎组的Th17、IL-17水平与EMPs水平呈正相关(r=0.830、0.644，P < 0.05)。结论: EMPs在过敏性紫癜的发病机制中起一定作用，EMPs升高可能是过敏性紫癜患儿肾脏受累的原因之一。

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