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  • Title: Functional simian virus 40 T antigen is expressed in hybrid cells having finite proliferative potential.
    Author: Pereira-Smith OM, Smith JR.
    Journal: Mol Cell Biol; 1987 Apr; 7(4):1541-4. PubMed ID: 3037326.
    Abstract:
    Simian virus 40-transformed human cells fused with other independently derived simian virus 40-transformed cells and tumor-derived cells containing activated H-ras and N-ras oncogenes yielded hybrids capable of indefinite division. Fusions with various other immortal cells yielded hybrids that had limited division potential. T antigen expressed in limited-division hybrids was functional for the induction of cellular DNA synthesis.
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