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  • Title: [Bone and calcium metabolism associated with malignancy. Malignancy-associated hypercalcemia.].
    Author: Tai N, Inoue D.
    Journal: Clin Calcium; 2018; 28(11):1503-1508. PubMed ID: 30374007.
    Abstract:
    Hypercalcemia is a poor prognostic factor and can be a direct cause of death in patients with malignancy. Here we provide a brief overview of pathology, etiology and management of malignancy associated hypercalcemia(MAH). MAH can be divided into two categories:humoral hypercalcemia of malignancy(HHM)caused by a systemic soluble factor secreted by the tumor;and local osteolytic hypercalcemia(LOH)in which tumor cells in situ enhance bone resorption. The standard treatment of MAH is intense hydration along with antiresorptive medications such as calcitonin, bisphosphonate and denosumab.
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