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  • Title: [Signet ring cell carcinoid of the appendix. Morphological, histochemical and immunohistochemical study of a case].
    Author: Moreno Casado J, Giménez Pizarro A, Río Suárez M, Barrio Lucía JA.
    Journal: Rev Esp Oncol; 1985; 32(2):281-9. PubMed ID: 3037654.
    Abstract:
    A case of carcinoid tumor of the appendix with "signet ring" cells pattern and asymptomatic clinical course is presented. The tumor was detected during a Bilroth I gastrectomy procedure. Mucin-secreting cells with cytoplasms often containing argentaffin and argyrophil granules was the predominant histologic pattern. Lack of neuron-specific enolase activity and their positivity for lysozyme and EMA marker indicate an origin from crypt cell and not a neural crest source. After simple appendectomy, the patient was healthy 3 years following surgery.
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