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  • Title: Monocyclic and tricyclic analogs of quinolones: mechanism of action.
    Author: Georgopapadakou NH, Dix BA, Angehrn P, Wick A, Olson GL.
    Journal: Antimicrob Agents Chemother; 1987 Apr; 31(4):614-6. PubMed ID: 3037999.
    Abstract:
    The mode of action of Ro 13-5478 and Ro 14-9578, monocyclic and tricyclic quinolone analogs, respectively, was examined for Escherichia coli and Staphylococcus aureus. The compounds showed antibacterial activity and effects on cell morphology, replicative DNA biosynthesis, and gyrase-catalyzed DNA supercoiling that were comparable to those shown by nalidixic acid and by oxolinic acid compounds. The results suggest that their site of action is DNA gyrase and that a bicyclic quinolone nucleus is not essential for activity.
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