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  • Title: Erythroid differentiation factor stimulates hydrolysis of polyphosphoinositide in Friend erythroleukemia cells.
    Author: Shibata H, Ogata E, Etoh Y, Shibai H, Kojima I.
    Journal: Biochem Biophys Res Commun; 1987 Jul 15; 146(1):187-93. PubMed ID: 3038104.
    Abstract:
    We examined an early action of erythroid differentiation factor (EDF), a polypeptide which induces differentiation of Friend murine erythroleukemia (MEL) cells. (Eto et al., Biochem. Biophys. Res. Commun. 142: 1095-1103, 1987). In MEL cells, EDF caused a rapid and transient increase in cytoplasmic concentration of free calcium, [Ca2+]c. EDF increased [Ca2+]c even in the absence of extracellular calcium. When [3H]inositol-labeled MEL cells were incubated with EDF, EDF rapidly increased radioactivity in inositol trisphosphate, bisphosphate and monophosphate. EDF also increased [3H] diacylglycerol in [3H]arachidonate-labeled MEL cells. These results indicate that EDF increases [Ca2+]c by stimulating hydrolysis of polyphosphoinositide.
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